How Curcumin Reduces Inflammation

 Curcumin, a compound found in turmeric, has been shown to have anti-inflammatory effects. It works by inhibiting the activity of a family of enzymes called cyclooxygenases (COX) and lipoxygenases (LOX) which are involved in the production of inflammatory compounds called prostaglandins and leukotrienes. Curcumin also modulates the activity of transcription factors, such as Nuclear Factor Kappa B (NF-kB) which regulates the expression of genes involved in inflammation. It also has antioxidant properties which can help to scavenge harmful reactive oxygen species (ROS) that can contribute to inflammation.

Curcumin is also known to interact with a variety of other molecular targets which are involved in inflammation, such as inhibiting the activity of certain pro-inflammatory cytokines, and blocking the activation of inflammatory signaling pathways.

It's important to note that the bioavailability of Curcumin is low and it is rapidly metabolized and eliminated, so it is often combined with other compounds such as Piperine (found in black pepper) to increase its bioavailability.  Piperine has been shown to increase the absorption of curcumin by up to 2000%

Fats can increase the bioavailability of certain compounds, including curcumin. The reason for this is that many fat-soluble compounds, such as curcumin, are not well absorbed in the gastrointestinal tract when taken on an empty stomach or without the presence of fats. When consumed with fats, these compounds are more easily absorbed into the bloodstream through the lymphatic system, rather than the circulatory system.

This process is known as "enhanced solubility and stability" that is the fat-soluble compounds are more stable in the presence of fats and thus more likely to survive the journey through the digestive tract and reach the bloodstream.

Consuming curcumin with a source of fat, such as coconut oil or ghee, can increase its bioavailabity.

Celery Juice

I was talking to a friend today about nutrition and he mentioned celery juice as his go to elixir, along with fasting and some other holistic nutrition efforts...

Celery juice has been touted as a healthful beverage, with some people claiming it can help with a variety of health conditions such as reducing inflammation, improving digestion and boosting energy levels. However, there is limited scientific research to support these claims. Celery does contain some vitamins and minerals, but it is not a significant source of any essential nutrients. Some people may find that drinking celery juice helps with symptoms of certain health conditions, but more research is needed to confirm these benefits.

It is believed to have anti-inflammatory properties due to the presence of certain compounds such as apigenin, luteolin and quercetin. These compounds are found in the celery leaves and stalks and are known to have antioxidant and anti-inflammatory effects. Additionally, celery contains other compounds such as polyacetylenes and flavonoids which also have anti-inflammatory properties.

Some people claim that drinking celery juice can help reduce inflammation in the body, but there is limited scientific research to support this claim. More studies are needed to determine the specific mechanisms by which celery juice may reduce inflammation and to confirm its effectiveness in treating inflammatory conditions.

It's also important to note that celery juice may interact with certain medications, so it's always best to consult a healthcare professional before adding celery juice to your diet, especially if you have an existing medical condition.

How much should I drink?  There is no specific recommended amount of celery juice to drink for health benefits, as the optimal dosage has not been established through scientific research. Some people who consume celery juice for its alleged health benefits recommend drinking 16 ounces (about 500 ml) of celery juice on an empty stomach in the morning. Others suggest drinking smaller amounts, such as 4-8 ounces, several times throughout the day.

It's important to note that drinking large amounts of celery juice may not be appropriate for everyone, and it's always best to consult a healthcare professional before making significant changes to your diet.

Also, drinking celery juice is not a substitute for other healthy lifestyle habits, such as eating a balanced diet, getting regular exercise, and getting enough sleep.

Almonds and Exercise

Almonds have been making some headlines in regards to how they affect exercise. Eating almonds after exercising can provide several benefits for your body. Almonds are a good source of protein, which can help to repair and rebuild muscle tissue after a workout. They also contain healthy fats, which can help to reduce inflammation and support overall cardiovascular health. Additionally, almonds are a good source of magnesium, which is important for muscle and nerve function and can help to reduce muscle cramps and soreness after exercise.

The protein, healthy fats, and fiber in almonds can also help to keep you feeling full and satisfied after a workout, which can help to prevent overeating and promote weight loss. The magnesium and potassium in almonds may also aid in replenishing electrolytes lost during intense workout or sweating. In summary, eating a handful of almonds as a post workout snack can provide you with a good balance of protein, healthy fats and minerals, helping with muscle rebuilding, inflammation, and satisfying hunger.

Additionally, 12,13-DiHOME (12,13-dihydroxy-9Z-octadecenoic acid) has been a strong point in how almonds affect exercise.  12,13 DiHOME is a derivative of linoleic acid, an omega-6 polyunsaturated fatty acid that is found in many vegetable oils and animal-derived products. It is an oxygenated fatty acid and a lipoxygenase metabolite that can be produced by many species of plants and animals. It has been found to have various biological activities, including anti-inflammatory, antimicrobial, and anticancer properties.

In the research field, 12,13-DiHOME is considered a PPAR-α agonist. PPAR-α is a protein that regulates the expression of genes involved in lipid metabolism, glucose homeostasis, and inflammation. Activation of PPAR-α by 12,13-DiHOME has been shown to promote the burning of fatty acids, improve insulin sensitivity, and reduce inflammation in animal models.

12,13-DiHOME has also been studied for its potential role in cancer treatment. Studies in cell culture and animal models have shown that it can inhibit the growth and spread of various types of cancer cells, including lung, breast, and colon cancer.

It is worth to notice that 12,13-DiHOME is not an extensively studied compound and most of the information currently available is based on pre-clinical studies, further research is needed to evaluate the potential therapeutic benefits of this compound in humans.

Post-workout results and reports of those who ate a handful of almonds prior to exercising include less tension and fatigue.